ABSTRACT: BACKGROUND:Self-medication practice (SMP) is the use of medication without the prescription of health care professionals. The major problems associated with self-medication practice have been drug resistance, drug side effects, wastage of resources, and serious health hazards including death. Thus, the main purpose of this study was to assess the prevalence of self-medication practice and its associated factors among adult household members in Meket District, Northeast Ethiopia. METHODS:A community based cross-sectional study was conducted among 722 adult household members in Meket District, from April 5 to May 5, 2017. The systematic random sampling method was used to select study participants. A pre-tested, structured questionnaire was used for data collection using an interviewer-administered technique. Epi-info version and SPSS version 22 were utilized for data entry and analysis, respectively. Univariate and multivariate logistic regression was used to identify association factors. RESULTS:The overall prevalence of self-medication was found to be 35.9%. Unmarried status (AOR?=?2.17, 95% CI?=?1.18, 4.01), previous experience of self-medication (AOR?=?1.78, 95% CI?=?1.22, 2.61), accessibility of pharmacies (AOR?=?3.71, 95% CI?=?1.31, 10.51), peer/family pressure (AOR?=?2.88, 95% CI?=?1.98, 4.18) and presence of medication at home (AOR?=?1.80, 95% CI?=?1.11, 2.92) were factors associated with self-medication practices. CONCLUSION:More than one-third of the study participants practiced self-medication. Thus, strengthening communities awareness on drug side effects and integrated efforts of individuals, communities, health facilities, and regulatory bodies are highly necessary.