Genetic loci for resistance to podocyte injury caused by the tensin2 gene deficiency in mice.

ABSTRACT:

Background

Tensin2 is a focal adhesion-localized multidomain protein expressed in various tissues, and its dysfunction leads to alterations in podocytes. However, these podocyte-related manifestations are dependent on murine strain. Tensin2 dysfunction results in susceptible strains developing podocyte foot process effacement and massive albuminuria, whereas podocytes in resistant strains remain almost intact. In our previous studies, quantitative trait loci analysis and congenic analysis using resistant C57BL/6J and susceptible ICGN mice identified a modifier locus associated with podocyte injury caused by tensin2 dysfunction on chromosome 2. However, the effect of this modifier locus on chromosome 2 is insufficient to explain the resistance of C57BL/6J mice to tensin2 dysfunction

SUBMITTER: Takahashi Y 

PROVIDER: S-EPMC5894168 | biostudies-literature | 2018 Apr

REPOSITORIES: biostudies-literature