Ontology highlight
ABSTRACT:
SUBMITTER: Samuelsen S
PROVIDER: S-EPMC5895021 | biostudies-literature | 2018
REPOSITORIES: biostudies-literature
PloS one 20180411 4
In this study, we developed a series of synthetic oligonucleotides that allowed us to investigate the details on the antigen recognition by autoimmune antibodies in localized scleroderma subjects. Besides dramatically improved analytical specificity of the assay, our data suggests a potential linking for antibodies to DNA to the biological status of disease state in localized scleroderma. Moreover, introducing chemical modifications into short synthetic deoxyribonucleic acid (DNA) and ribonuclei ...[more]