Ghrelin is a persistent biomarker for chronic stress exposure in adolescent rats and humans.
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ABSTRACT:
SUBMITTER: Yousufzai MIUA
PROVIDER: S-EPMC5895712 | biostudies-literature | 2018 Apr
REPOSITORIES: biostudies-literature
Publications
Ghrelin is a persistent biomarker for chronic stress exposure in adolescent rats and humans.
Yousufzai Muhammad I Ul Akbar MIUA Harmatz Elia S ES Shah Mohsin M Malik Muhammad O MO Goosens Ki A KA
Translational psychiatry 20180411 1
Prolonged stressor exposure in adolescence enhances the risk of developing stress-sensitive mental illnesses, including posttraumatic stress disorder (PTSD), for many years following exposure cessation, but the biological underpinnings of this long-term vulnerability are unknown. We show that severe stressor exposure increased circulating levels of the hormone acyl-ghrelin in adolescent rats for at least 130 days and in adolescent humans for at least 4.5 years. Using a rodent model of longitudin ...[more]
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