Dataset Information

Persistent changes in the glutamatergic and GABAergic signaling in adolescent rats exposed developmentally to chlorpyrifos

ABSTRACT: Male Sprague Dawley rats were treated daily by oral gavage with either corn oil, chlorpyrifos, or PF-04457845 (selective FAAH inhibitor) from postnatal day10-16. The rats were scarified on postnatal day 38, and brains were collected and stored at -80˚C. Amygdala was isolated from the brain, homogenized the tissue, proteins were quantified, trypsin digested, and analyzed by LC ESI MS/MS.

INSTRUMENT(S): LTQ Orbitrap Velos

ORGANISM(S): Rattus Norvegicus (rat)

TISSUE(S): Brain

SUBMITTER: Navatha Alugubelly

LAB HEAD: Russell L.Carr

PROVIDER: PXD017405 | Pride | 2022-08-11

REPOSITORIES: Pride

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Persistent proteomic changes in glutamatergic and GABAergic signaling in the amygdala of adolescent rats exposed to chlorpyrifos as juveniles.

Alugubelly Navatha N Mohammed Afzaal N AN Carr Russell L RL

Neurotoxicology 20210528

Chlorpyrifos (CPF) remains one of the most widely used organophosphorus insecticides (OPs) despite the concerns about its developmental neurotoxicity. Developmental exposure to CPF has long-lasting negative impacts, including abnormal emotional behaviors. These negative impacts are observed at exposure levels do not cause inhibition of acetylcholinesterase, the canonical target of OPs. Exposure to CPF at these levels inhibits the endocannabinoid metabolizing enzyme fatty acid amide hydrolase (FA ...[more]

PMID: 34058248

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