Ontology highlight
ABSTRACT:
SUBMITTER: Kieper SN
PROVIDER: S-EPMC5896167 | biostudies-literature | 2018 Mar
REPOSITORIES: biostudies-literature
Kieper Sebastian N SN Almendros Cristóbal C Behler Juliane J McKenzie Rebecca E RE Nobrega Franklin L FL Haagsma Anna C AC Vink Jochem N A JNA Hess Wolfgang R WR Brouns Stan J J SJJ
Cell reports 20180301 13
CRISPR-Cas systems adapt their immunological memory against their invaders by integrating short DNA fragments into clustered regularly interspaced short palindromic repeat (CRISPR) loci. While Cas1 and Cas2 make up the core machinery of the CRISPR integration process, various class I and II CRISPR-Cas systems encode Cas4 proteins for which the role is unknown. Here, we introduced the CRISPR adaptation genes cas1, cas2, and cas4 from the type I-D CRISPR-Cas system of Synechocystis sp. 6803 into E ...[more]