Ontology highlight
ABSTRACT:
SUBMITTER: Roswall P
PROVIDER: S-EPMC5896729 | biostudies-literature | 2018 May
REPOSITORIES: biostudies-literature
Nature medicine 20180312 4
Breast tumors of the basal-like, hormone receptor-negative subtype remain an unmet clinical challenge, as there is high rate of recurrence and poor survival in patients following treatment. Coevolution of the malignant mammary epithelium and its underlying stroma instigates cancer-associated fibroblasts (CAFs) to support most, if not all, hallmarks of cancer progression. Here we delineate a previously unappreciated role for CAFs as determinants of the molecular subtype of breast cancer. We ident ...[more]