Ontology highlight
ABSTRACT:
SUBMITTER: Jackson L
PROVIDER: S-EPMC5896883 | biostudies-literature | 2018 Mar
REPOSITORIES: biostudies-literature
Jackson Laurelle L Hunter Jessica J Cele Sandile S Ferreira Isabella Markham IM Young Andrew C AC Karim Farina F Madansein Rajhmun R Dullabh Kaylesh J KJ Chen Chih-Yuan CY Buckels Noel J NJ Ganga Yashica Y Khan Khadija K Khan Khadija K Boulle Mikael M Lustig Gila G Neher Richard A RA Sigal Alex A
eLife 20180320
HIV has been reported to be cytotoxic in vitro and in lymph node infection models. Using a computational approach, we found that partial inhibition of transmissions of multiple virions per cell could lead to increased numbers of live infected cells. If the number of viral DNA copies remains above one after inhibition, then eliminating the surplus viral copies reduces cell death. Using a cell line, we observed increased numbers of live infected cells when infection was partially inhibited with th ...[more]