Ontology highlight
ABSTRACT:
SUBMITTER: Kozlov G
PROVIDER: S-EPMC5897132 | biostudies-literature | 2018 Feb
REPOSITORIES: biostudies-literature
Kozlov Guennadi G Wong Kathy K Gehring Kalle K
Proteins 20171129 2
Legionella pneumophila is a pathogen causing severe pneumonia in humans called Legionnaires' disease. Lem22 is a previously uncharacterized effector protein conserved in multiple Legionella strains. Here, we report the crystal structure of Lem22 from the Philadelphia strain, also known as lpg2328, at 1.40 Å resolution. The structure shows an up-and-down three-helical bundle with a significant structural similarity to a number of protein-binding domains involved in apoptosis and membrane traffick ...[more]