Ontology highlight
ABSTRACT:
SUBMITTER: Morar M
PROVIDER: S-EPMC4715502 | biostudies-literature | 2015 Dec
REPOSITORIES: biostudies-literature
Morar Mariya M Evdokimova Elena E Chang Changsoo C Ensminger Alexander W AW Savchenko Alexei A
Proteins 20151014 12
Legionella pneumophila, the intracellular pathogen that can cause severe pneumonia known as Legionnaire's disease, translocates close to 300 effectors inside the host cell using Dot/Icm type IVB secretion system. The structure and function for the majority of these effector proteins remains unknown. Here, we present the crystal structure of the L. pneumophila effector Lem10. The structure reveals a multidomain organization with the largest C-terminal domain showing strong structural similarity t ...[more]