Ontology highlight
ABSTRACT:
SUBMITTER: Sevin M
PROVIDER: S-EPMC5897330 | biostudies-literature | 2018 Apr
REPOSITORIES: biostudies-literature
Sevin Margaux M Kubovcakova Lucia L Pernet Nicolas N Causse Sébastien S Vitte Franck F Villeval Jean Luc JL Lacout Catherine C Cordonnier Marine M Rodrigues-Lima Fernando F Chanteloup Gaétan G Mosca Matthieu M Chrétien Marie-Lorraine ML Bastie Jean Noël JN Audia Sylvain S Sagot Paul P Ramla Selim S Martin Laurent L Gleave Martin M Mezger Valérie V Skoda Radek R Plo Isabelle I Garrido Carmen C Girodon François F de Thonel Aurélie A
Nature communications 20180412 1
Heat shock protein 27 (HSP27/HSPB1) is a stress-inducible chaperone that facilitates cancer development by its proliferative and anti-apoptotic functions. The OGX-427 antisense oligonucleotide against HSP27 has been reported to be beneficial against idiopathic pulmonary fibrosis. Here we show that OGX-427 is effective in two murine models of thrombopoietin- and JAKV617F-induced myelofibrosis. OGX-427 limits disease progression and is associated with a reduction in spleen weight, in megakaryocyte ...[more]