Ontology highlight
ABSTRACT:
SUBMITTER: Keller A
PROVIDER: S-EPMC5824979 | biostudies-other | 2018 Mar
REPOSITORIES: biostudies-other
Keller Alexandra A Wingelhofer Bettina B Peter Barbara B Bauer Karin K Berger Daniela D Gamperl Susanne S Reifinger Martin M Cerny-Reiterer Sabine S Moriggl Richard R Willmann Michael M Valent Peter P Hadzijusufovic Emir E
Veterinary and comparative oncology 20170411 1
<h4>Background</h4>Mastocytoma are frequently diagnosed cutaneous neoplasms in dogs. In non-resectable mastocytoma patients, novel targeted drugs are often applied. The transcription factor STAT5 has been implicated in the survival of human neoplastic mast cells (MC). Our study evaluated the JAK2/STAT5 pathway as a novel target in canine mastocytoma.<h4>Materials and methods</h4>We employed inhibitors of JAK2 (R763, TG101348, AZD1480, ruxolitinib) and STAT5 (pimozide, piceatannol) and evaluated ...[more]