Ontology highlight
ABSTRACT:
SUBMITTER: Andorfer MC
PROVIDER: S-EPMC5898195 | biostudies-literature | 2017 Nov
REPOSITORIES: biostudies-literature
Andorfer Mary C MC Belsare Ketaki D KD Girlich Anna M AM Lewis Jared C JC
Chembiochem : a European journal of chemical biology 20170922 21
The remarkable site selectivity and broad substrate scope of flavin-dependent halogenases (FDHs) has led to much interest in their potential as biocatalysts. Multiple engineering efforts have demonstrated that FDHs can be tuned for non-native substrate scope and site selectivity. FDHs have also proven useful as in vivo biocatalysts and have been successfully incorporated into biosynthetic pathways to build new chlorinated aromatic compounds in several heterologous organisms. In both cases, reduc ...[more]