Ontology highlight
ABSTRACT:
SUBMITTER: Shepherd SA
PROVIDER: S-EPMC5659210 | biostudies-literature | 2015 Jun
REPOSITORIES: biostudies-literature
Shepherd Sarah A SA Karthikeyan Chinnan C Latham Jonathan J Struck Anna-Winona AW Thompson Mark L ML Menon Binuraj R K BRK Styles Matthew Q MQ Levy Colin C Leys David D Micklefield Jason J
Chemical science 20150410 6
Flavin-dependent halogenases are potentially valuable biocatalysts for the regioselective halogenation of aromatic compounds. These enzymes, utilising benign inorganic halides, offer potential advantages over traditional non-enzymatic halogenation chemistry that often lacks regiocontrol and requires deleterious reagents. Here we extend the biocatalytic repertoire of the tryptophan halogenases, demonstrating how these enzymes can halogenate a range of alternative aryl substrates. Using structure ...[more]