Ontology highlight
ABSTRACT:
SUBMITTER: Liu B
PROVIDER: S-EPMC5898216 | biostudies-literature | 2015 Jun
REPOSITORIES: biostudies-literature
Liu Bing B Ouyang Songying S Makarova Kira S KS Xia Qiu Q Zhu Yanping Y Li Zhimeng Z Guo Li L Koonin Eugene V EV Liu Zhi-Jie ZJ Huang Li L
Nature communications 20150622
Archaea encode a eukaryotic-type primase comprising a catalytic subunit (PriS) and a noncatalytic subunit (PriL). Here we report the identification of a primase noncatalytic subunit, denoted PriX, from the hyperthermophilic archaeon Sulfolobus solfataricus. Like PriL, PriX is essential for the survival of the organism. The crystallographic analysis complemented by sensitive sequence comparisons shows that PriX is a diverged homologue of the C-terminal domain of PriL but lacks the iron-sulfur clu ...[more]