Shared molecular neuropathology across major psychiatric disorders parallels polygenic overlap.
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ABSTRACT:
SUBMITTER: Gandal MJ
PROVIDER: S-EPMC5898828 | biostudies-literature | 2018 Feb
REPOSITORIES: biostudies-literature
Publications
Shared molecular neuropathology across major psychiatric disorders parallels polygenic overlap.
Gandal Michael J MJ Haney Jillian R JR Parikshak Neelroop N NN Leppa Virpi V Ramaswami Gokul G Hartl Chris C Schork Andrew J AJ Appadurai Vivek V Buil Alfonso A Buil Alfonso A Werge Thomas M TM Liu Chunyu C White Kevin P KP Horvath Steve S Geschwind Daniel H DH
Science (New York, N.Y.) 20180201 6376
The predisposition to neuropsychiatric disease involves a complex, polygenic, and pleiotropic genetic architecture. However, little is known about how genetic variants impart brain dysfunction or pathology. We used transcriptomic profiling as a quantitative readout of molecular brain-based phenotypes across five major psychiatric disorders-autism, schizophrenia, bipolar disorder, depression, and alcoholism-compared with matched controls. We identified patterns of shared and distinct gene-express ...[more]
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