Ontology highlight
ABSTRACT:
SUBMITTER: Milewska A
PROVIDER: S-EPMC5899082 | biostudies-literature | 2018 Apr
REPOSITORIES: biostudies-literature
Milewska Aleksandra A Kindler Eveline E Vkovski Philip P Zeglen Slawomir S Ochman Marek M Thiel Volker V Rajfur Zenon Z Pyrc Krzysztof K
Scientific reports 20180413 1
APOBEC3 family members are cytidine deaminases with roles in intrinsic responses to infection by retroviruses and retrotransposons, and in the control of other DNA viruses, such as herpesviruses, parvoviruses and hepatitis B virus. Although effects of APOBEC3 members on viral DNA have been demonstrated, it is not known whether they edit RNA genomes through cytidine deamination. Here, we investigated APOBEC3-mediated restriction of Coronaviridae. In experiments in vitro, three human APOBEC3 prote ...[more]