Ontology highlight
ABSTRACT:
SUBMITTER: Shull JD
PROVIDER: S-EPMC5899232 | biostudies-literature | 2018 Mar
REPOSITORIES: biostudies-literature
Shull James D JD Dennison Kirsten L KL Chack Aaron C AC Trentham-Dietz Amy A
Physiological genomics 20180126 3
Numerous laboratory and epidemiologic studies strongly implicate endogenous and exogenous estrogens in the etiology of breast cancer. Data summarized herein suggest that the ACI rat model of 17β-estradiol (E2)-induced mammary cancer is unique among rodent models in the extent to which it faithfully reflects the etiology and biology of luminal types of breast cancer, which together constitute ~70% of all breast cancers. E2 drives cancer development in this model through mechanisms that are largel ...[more]