24 vs. 72 hours of hypothermia for pediatric cardiac arrest: A pilot, randomized controlled trial.

ABSTRACT:

Aim

Children surviving cardiac arrest (CA) lack proven neuroprotective therapies. The role of biomarkers in assessing response to interventions is unknown. We hypothesized that 72 versus 24 h of hypothermia (HT) would produce more favorable biomarker profiles after pediatric CA.

Methods

This single center pilot randomized trial tested HT (33 ± 1 °C) for 24 vs. 72 h in 34 children with CA. Children comatose after return of circulation aged 1 week to 17 years and treated with HT by their physician were eligible. Serum was collected twice daily on days 1-4 and once on day 7. Mortality was assessed at 6 months.

Results

Patient characteristics, baseline biomarker concentrations, and adverse events were similar between groups. Eight (47%) and 4 (24%) children died in the 24

SUBMITTER: Fink EL 

PROVIDER: S-EPMC5899619 | biostudies-literature | 2018 May

REPOSITORIES: biostudies-literature