Ontology highlight
ABSTRACT:
SUBMITTER: Zhang H
PROVIDER: S-EPMC5900708 | biostudies-literature | 2018 Mar
REPOSITORIES: biostudies-literature
Zhang Heng H Zhou Bo B Qin Su S Xu Jing J Harding Rachel R Tempel Wolfram W Nayak Vinod V Li Yanjun Y Loppnau Peter P Dou Yali Y Min Jinrong J
Genes & development 20180321 5-6
The mixed-lineage leukemia (MLL)-AF10 fusion oncoprotein recruits DOT1L to the homeobox A (<i>HOXA</i>) gene cluster through its octapeptide motif leucine zipper (OM-LZ), thereby inducing and maintaining the MLL-AF10-associated leukemogenesis. However, the recognition mechanism between DOT1L and MLL-AF10 is unclear. Here, we present the crystal structures of both apo AF10<sup>OM-LZ</sup> and its complex with the coiled-coil domain of DOT1L. Disruption of the DOT1L-AF10 interface abrogates MLL-AF ...[more]