Ontology highlight
ABSTRACT:
SUBMITTER: Sanders DB
PROVIDER: S-EPMC5900968 | biostudies-literature | 2018 Apr
REPOSITORIES: biostudies-literature
Sanders Donald B DB Juel Vern C VC Harati Yadollah Y Smith A Gordon AG Peltier Amanda C AC Marburger Tessa T Lou Jau-Shin JS Pascuzzi Robert M RM Richman David P DP Xie Tai T Demmel Valentin V Jacobus Laura R LR Aleš Kathy L KL Jacobus David P DP
Muscle & nerve 20180202 4
<h4>Introduction</h4>3,4-diaminopyridine has been used to treat Lambert-Eaton myasthenia (LEM) for 30 years despite the lack of conclusive evidence of efficacy.<h4>Methods</h4>We conducted a randomized double-blind placebo-controlled withdrawal study in patients with LEM who had been on stable regimens of 3,4-diaminopyridine base (3,4-DAP) for ≥ 3 months. The primary efficacy endpoint was >30% deterioration in triple timed up-and-go (3TUG) times during tapered drug withdrawal. The secondary endp ...[more]