Ontology highlight
ABSTRACT:
SUBMITTER: Wu N
PROVIDER: S-EPMC5901959 | biostudies-literature | 2017 Jul
REPOSITORIES: biostudies-literature
Wu Nan N Nguyen Quy Q Wan Ying Y Zhou Tiaohao T Venter Julie J Frampton Gabriel A GA DeMorrow Sharon S Pan Duojia D Meng Fanyin F Glaser Shannon S Alpini Gianfranco G Bai Haibo H
Laboratory investigation; a journal of technical methods and pathology 20170605 7
The Hippo signaling pathway and the Notch signaling pathway are evolutionary conserved signaling cascades that have important roles in embryonic development of many organs. In murine liver, disruption of either pathway impairs intrahepatic bile duct development. Recent studies suggested that the Notch signaling receptor Notch2 is a direct transcriptional target of the Hippo signaling pathway effector YAP, and the Notch signaling is a major mediator of the Hippo signaling in maintaining biliary c ...[more]