Ontology highlight
ABSTRACT:
SUBMITTER: Gonzalez Herrera KN
PROVIDER: S-EPMC5902027 | biostudies-literature | 2018 Feb
REPOSITORIES: biostudies-literature
Gonzalez Herrera Karina N KN Zaganjor Elma E Ishikawa Yoshinori Y Spinelli Jessica B JB Yoon Haejin H Lin Jia-Ren JR Satterstrom F Kyle FK Ringel Alison A Mulei Stacy S Souza Amanda A Gorham Joshua M JM Benson Craig C CC Seidman Jonathan G JG Sorger Peter K PK Clish Clary B CB Haigis Marcia C MC
Cell reports 20180201 8
Sirtuin 3 (SIRT3) is a NAD<sup>+</sup>-dependent deacetylase downregulated in aging and age-associated diseases such as cancer and neurodegeneration and in high-fat diet (HFD)-induced metabolic disorders. Here, we performed a small-molecule screen and identified an unexpected metabolic vulnerability associated with SIRT3 loss. Azaserine, a glutamine analog, was the top compound that inhibited growth and proliferation of cells lacking SIRT3. Using stable isotope tracing of glutamine, we observed ...[more]