Ontology highlight
ABSTRACT:
SUBMITTER: Sarria I
PROVIDER: S-EPMC5902029 | biostudies-literature | 2018 Mar
REPOSITORIES: biostudies-literature
Sarria Ignacio I Cao Yan Y Wang Yuchen Y Ingram Norianne T NT Orlandi Cesare C Kamasawa Naomi N Kolesnikov Alexander V AV Pahlberg Johan J Kefalov Vladimir J VJ Sampath Alapakkam P AP Martemyanov Kirill A KA
Cell reports 20180301 13
Cone photoreceptors scale dynamically the sensitivity of responses to maintain responsiveness across wide range of changes in luminance. Synaptic changes contribute to this adaptation, but how this process is coordinated at the molecular level is poorly understood. Here, we report that a cell adhesion-like molecule, LRIT1, is enriched selectively at cone photoreceptor synapses where it engages in a trans-synaptic interaction with mGluR6, the principal receptor in postsynaptic ON-bipolar cells. T ...[more]