Ontology highlight
ABSTRACT:
SUBMITTER: Gregorova S
PROVIDER: S-EPMC5902161 | biostudies-literature | 2018 Mar
REPOSITORIES: biostudies-literature
Gregorova Sona S Gergelits Vaclav V Chvatalova Irena I Bhattacharyya Tanmoy T Valiskova Barbora B Fotopulosova Vladana V Jansa Petr P Wiatrowska Diana D Forejt Jiri J
eLife 20180314
Hybrid sterility is one of the reproductive isolation mechanisms leading to speciation. <i>Prdm9</i>, the only known vertebrate hybrid-sterility gene, causes failure of meiotic chromosome synapsis and infertility in male hybrids that are the offspring of two mouse subspecies. Within species, <i>Prdm9</i> determines the sites of programmed DNA double-strand breaks (DSBs) and meiotic recombination hotspots. To investigate the relation between <i>Prdm9</i>-controlled meiotic arrest and asynapsis, w ...[more]