Ontology highlight
ABSTRACT:
SUBMITTER: Wang L
PROVIDER: S-EPMC6324875 | biostudies-literature | 2018 Dec
REPOSITORIES: biostudies-literature
Wang Liu L Valiskova Barbora B Forejt Jiri J
eLife 20181228
PR domain containing 9 (<i>Prdm9</i>) is specifying hotspots of meiotic recombination but in hybrids between two mouse subspecies <i>Prdm9</i> controls failure of meiotic chromosome synapsis and hybrid male sterility. We have previously reported that <i>Prdm9</i>-controlled asynapsis and meiotic arrest are conditioned by the inter-subspecific heterozygosity of the hybrid genome and we presumed that the insufficient number of properly repaired PRDM9-dependent DNA double-strand breaks (DSBs) cause ...[more]