Ontology highlight
ABSTRACT:
SUBMITTER: Levin MD
PROVIDER: S-EPMC5902185 | biostudies-literature | 2017 Jun
REPOSITORIES: biostudies-literature
Levin Mark D MD Chen Tiffany Q TQ Neubig Megan E ME Hong Cynthia M CM Theulier Cyril A CA Kobylianskii Ilia J IJ Janabi Mustafa M O'Neil James P JP Toste F Dean FD
Science (New York, N.Y.) 20170601 6344
The biological properties of trifluoromethyl compounds have led to their ubiquity in pharmaceuticals, yet their chemical properties have made their preparation a substantial challenge, necessitating innovative chemical solutions. We report the serendipitous discovery of a borane-catalyzed formal C(sp<sup>3</sup>)-CF<sub>3</sub> reductive elimination from Au(III) that accesses these compounds by a distinct mechanism proceeding via fluoride abstraction, migratory insertion, and C-F reductive elimi ...[more]