Ontology highlight
ABSTRACT:
SUBMITTER: Lee JY
PROVIDER: S-EPMC5902554 | biostudies-literature | 2018 Apr
REPOSITORIES: biostudies-literature
Lee Ju Youn JY Han Seung Hoon SH Park Min Hee MH Baek Bosung B Song Im-Sook IS Choi Min-Koo MK Takuwa Yoh Y Ryu Hoon H Kim Seung Hyun SH He Xingxuan X Schuchman Edward H EH Bae Jae-Sung JS Jin Hee Kyung HK
Nature communications 20180416 1
Although many reports have revealed the importance of defective microglia-mediated amyloid β phagocytosis in Alzheimer's disease (AD), the underlying mechanism remains to be explored. Here we demonstrate that neurons in the brains of patients with AD and AD mice show reduction of sphingosine kinase1 (SphK1), leading to defective microglial phagocytosis and dysfunction of inflammation resolution due to decreased secretion of specialized proresolving mediators (SPMs). Elevation of SphK1 increased ...[more]