Ontology highlight
ABSTRACT:
SUBMITTER: Nobili A
PROVIDER: S-EPMC5382255 | biostudies-literature | 2017 Apr
REPOSITORIES: biostudies-literature
Nobili Annalisa A Latagliata Emanuele Claudio EC Viscomi Maria Teresa MT Cavallucci Virve V Cutuli Debora D Giacovazzo Giacomo G Krashia Paraskevi P Rizzo Francesca Romana FR Marino Ramona R Federici Mauro M De Bartolo Paola P Aversa Daniela D Dell'Acqua Maria Concetta MC Cordella Alberto A Sancandi Marco M Keller Flavio F Petrosini Laura L Puglisi-Allegra Stefano S Mercuri Nicola Biagio NB Coccurello Roberto R Berretta Nicola N D'Amelio Marcello M
Nature communications 20170403
Alterations of the dopaminergic (DAergic) system are frequently reported in Alzheimer's disease (AD) patients and are commonly linked to cognitive and non-cognitive symptoms. However, the cause of DAergic system dysfunction in AD remains to be elucidated. We investigated alterations of the midbrain DAergic system in the Tg2576 mouse model of AD, overexpressing a mutated human amyloid precursor protein (APPswe). Here, we found an age-dependent DAergic neuron loss in the ventral tegmental area (VT ...[more]