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Application of Solid-State NMR to Reveal Structural Differences in Cefazolin Sodium Pentahydrate From Different Manufacturing Processes.

ABSTRACT: Solid-state Nuclear magnetic resonance, thermogravimetric analysis, X-ray diffraction, and Fourier-transform infrared spectroscopy were combined with theoretical calculation to investigate different crystal packings of ?-cefazolin sodium obtained from three different vendors and conformational polymorphism was identified to exist in ?-cefazolin sodium. Marginal differences observed among cefazolin sodium pentahydrate 1, 2, and 3 were speculated as being caused by the proportion of conformation 2.

SUBMITTER: Tian Y

PROVIDER: S-EPMC5902681 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature

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Application of Solid-State NMR to Reveal Structural Differences in Cefazolin Sodium Pentahydrate From Different Manufacturing Processes.

Tian Ye Y Wang Wei D WD Zou Wen-Bo WB Qian Jian-Qin JQ Hu Chang-Qin CQ

Frontiers in chemistry 20180410

Solid-state Nuclear magnetic resonance, thermogravimetric analysis, X-ray diffraction, and Fourier-transform infrared spectroscopy were combined with theoretical calculation to investigate different crystal packings of α-cefazolin sodium obtained from three different vendors and conformational polymorphism was identified to exist in α-cefazolin sodium. Marginal differences observed among cefazolin sodium pentahydrate 1, 2, and 3 were speculated as being caused by the proportion of conformation < ...[more]

PMID: 29692988

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