Mutations, Cancer and the Telomere Length Paradox.
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ABSTRACT:
SUBMITTER: Aviv A
PROVIDER: S-EPMC5903276 | biostudies-literature | 2017 Apr
REPOSITORIES: biostudies-literature
Publications
Mutations, Cancer and the Telomere Length Paradox.
Aviv Abraham A Anderson James J JJ Shay Jerry W JW
Trends in cancer 20170327 4
Individuals with short telomeres should be at increased risk for cancer, since short telomeres lead to genomic instability - a hallmark of cancer. However, individuals with long telomeres also display an increased risk for major cancers, thus creating a cancer-telomere length (TL) paradox. The two-stage clonal expansion model we propose is based on the thesis that a series of mutational hits (1st Hit) at the stem-cell level generates a clone with replicative advantage. A series of additional mut ...[more]
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