Telomere Targeting Approaches in Cancer: Beyond Length Maintenance.
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ABSTRACT:
SUBMITTER: Vertecchi E
PROVIDER: S-EPMC8998427 | biostudies-literature | 2022 Mar
REPOSITORIES: biostudies-literature
Publications
Telomere Targeting Approaches in Cancer: Beyond Length Maintenance.
Vertecchi Eleonora E Rizzo Angela A Salvati Erica E
International journal of molecular sciences 20220329 7
Telomeres are crucial structures that preserve genome stability. Their progressive erosion over numerous DNA duplications determines the senescence of cells and organisms. As telomere length homeostasis is critical for cancer development, nowadays, telomere maintenance mechanisms are established targets in cancer treatment. Besides telomere elongation, telomere dysfunction impinges on intracellular signaling pathways, in particular DNA damage signaling and repair, affecting cancer cell survival ...[more]
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