Ontology highlight
ABSTRACT:
SUBMITTER: Fukumoto T
PROVIDER: S-EPMC5903572 | biostudies-literature | 2018 Mar
REPOSITORIES: biostudies-literature
Fukumoto Takeshi T Park Pyoung Hwa PH Wu Shuai S Fatkhutdinov Nail N Karakashev Sergey S Nacarelli Timothy T Kossenkov Andrew V AV Speicher David W DW Jean Stephanie S Zhang Lin L Wang Tian-Li TL Shih Ie-Ming IM Conejo-Garcia Jose R JR Bitler Benjamin G BG Zhang Rugang R
Cell reports 20180301 13
ARID1A, a subunit of the SWI/SNF complex, is among the most frequently mutated genes across cancer types. ARID1A is mutated in more than 50% of ovarian clear cell carcinomas (OCCCs), diseases that have no effective therapy. Here, we show that ARID1A mutation confers sensitivity to pan-HDAC inhibitors such as SAHA in ovarian cancers. This correlated with enhanced growth suppression induced by the inhibition of HDAC2 activity in ARID1A-mutated cells. HDAC2 interacts with EZH2 in an ARID1A status-d ...[more]