Canonical PI3K? signaling in myeloid cells restricts Trypanosoma cruzi infection and dampens chagasic myocarditis.
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ABSTRACT:
SUBMITTER: Silva MC
PROVIDER: S-EPMC5904108 | biostudies-literature | 2018 Apr
REPOSITORIES: biostudies-literature
Publications
Canonical PI3Kγ signaling in myeloid cells restricts Trypanosoma cruzi infection and dampens chagasic myocarditis.
Silva Maria C MC Davoli-Ferreira Marcela M Medina Tiago S TS Sesti-Costa Renata R Silva Grace K GK Lopes Carla D CD Cardozo Lucas E LE Gava Fábio N FN Lyroni Konstantina K Dias Fabrício C FC Frade Amanda F AF Baron Monique M Nakaya Helder I HI Figueiredo Florêncio F Alves-Filho José C JC Cunha Fernando Q FQ Tsatsanis Christos C Chevillard Christophe C Cunha-Neto Edecio E Hirsch Emilio E Silva João S JS Cunha Thiago M TM
Nature communications 20180417 1
Chagas disease is caused by infection with the protozoan Trypanosoma cruzi (T. cruzi) and is an important cause of severe inflammatory heart disease. However, the mechanisms driving Chagas disease cardiomyopathy have not been completely elucidated. Here, we show that the canonical PI3Kγ pathway is upregulated in both human chagasic hearts and hearts of acutely infected mice. PI3Kγ-deficient mice and mutant mice carrying catalytically inactive PI3Kγ are more susceptible to T. cruzi infection. The ...[more]
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