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A Glimpse Into the Structure and Function of Atypical Type I Chaperonins.

ABSTRACT: Chaperonins are a subclass of molecular chaperones that assist cellular proteins to fold and assemble into their native shape. Much work has been done on Type I chaperonins, which has elucidated their elegant mechanism. Some debate remains about the details in these mechanisms, but nonetheless the roles of these in helping protein folding have been understood in great depth. In this review we discuss the known functions of atypical Type I chaperonins, highlighting evolutionary aspects that might lead chaperonins to perform alternate functions.

SUBMITTER: Ansari MY

PROVIDER: S-EPMC5904260 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature

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A Glimpse Into the Structure and Function of Atypical Type I Chaperonins.

Ansari Mohammed Y MY Mande Shekhar C SC

Frontiers in molecular biosciences 20180411

Chaperonins are a subclass of molecular chaperones that assist cellular proteins to fold and assemble into their native shape. Much work has been done on Type I chaperonins, which has elucidated their elegant mechanism. Some debate remains about the details in these mechanisms, but nonetheless the roles of these in helping protein folding have been understood in great depth. In this review we discuss the known functions of atypical Type I chaperonins, highlighting evolutionary aspects that might ...[more]

PMID: 29696145

Similar Datasets

Prokaryotic Chaperonins as Experimental Models for Elucidating Structure-Function Abnormalities of Human Pathogenic Mutant Counterparts.

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Chaperonins: Nanocarriers with Biotechnological Applications.

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