Ontology highlight
ABSTRACT:
SUBMITTER: Wezyk M
PROVIDER: S-EPMC5904768 | biostudies-literature | 2018
REPOSITORIES: biostudies-literature
Wezyk Michalina M Spólnicka Magdalena M Pośpiech Ewelina E Pepłońska Beata B Zbieć-Piekarska Renata R Ilkowski Jan J Styczyńska Maria M Barczak Anna A Zboch Marzena M Filipek-Gliszczynska Anna A Skrzypczak Magdalena M Ginalski Krzysztof K Kabza Michał M Makałowska Izabela I Barcikowska-Kotowicz Maria M Branicki Wojciech W Żekanowski Cezary C
Oxidative medicine and cellular longevity 20180404
Epigenetic mechanisms play an important role in the development and progression of various neurodegenerative diseases. Abnormal methylation of numerous genes responsible for regulation of transcription, DNA replication, and apoptosis has been linked to Alzheimer's disease (AD) pathology. We have recently performed whole transcriptome profiling of familial early-onset Alzheimer's disease (fEOAD) patient-derived fibroblasts. On this basis, we demonstrated a strong dysregulation of cell cycle check ...[more]