Composite mathematical modeling of calcium signaling behind neuronal cell death in Alzheimer's disease.

ABSTRACT: BACKGROUND:Alzheimer's disease (AD) is a progressive neurological disorder, recognized as the most common cause of dementia affecting people aged 65 and above. AD is characterized by an increase in amyloid metabolism, and by the misfolding and deposition of β-amyloid oligomers in and around neurons in the brain. These processes remodel the calcium signaling mechanism in neurons, leading to cell death via apoptosis. Despite accumulating knowledge about the biological processes underlying AD, mathematical models to date are restricted to depicting only a small portion of the pathology. RESULTS:Here, we integrated multiple mathematical models to analyze and understand the relationship among amyloid depositions, calcium signaling and mitochondrial permeability transition pore (PTP) related cel

SUBMITTER: Ranjan B 

PROVIDER: S-EPMC5907315 | biostudies-literature | 2018 Apr

REPOSITORIES: biostudies-literature