Ontology highlight
ABSTRACT:
SUBMITTER: Court R
PROVIDER: S-EPMC5905389 | biostudies-literature | 2018 May
REPOSITORIES: biostudies-literature
Court R R Chirehwa M T MT Wiesner L L Wright B B Smythe W W Kramer N N McIlleron H H
The international journal of tuberculosis and lung disease : the official journal of the International Union against Tuberculosis and Lung Disease 20180501 5
<h4>Setting</h4>Rifampicin (RMP) drives treatment response in drug-susceptible tuberculosis. Low RMP concentrations increase the risk of poor outcomes, and drug quality needs to be excluded as a contributor to low RMP exposure.<h4>Objectives and design</h4>We performed an open-label, three-way cross-over study of three licensed RMP-containing formulations widely used in South Africa to evaluate the bioavailability of RMP in a two-drug fixed-dose combination tablet (2FDC) and a four-drug FDC (4FD ...[more]