Implications of Antimicrobial Combinations in Complex Wound Biofilms Containing Fungi.
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ABSTRACT:
SUBMITTER: Townsend EM
PROVIDER: S-EPMC5571281 | biostudies-literature | 2017 Sep
REPOSITORIES: biostudies-literature
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Implications of Antimicrobial Combinations in Complex Wound Biofilms Containing Fungi.
Townsend Eleanor M EM Sherry Leighann L Kean Ryan R Hansom Donald D Mackay William G WG Williams Craig C Butcher John J Ramage Gordon G
Antimicrobial agents and chemotherapy 20170824 9
Diabetic foot ulcer treatment currently focuses on targeting bacterial biofilms, while dismissing fungi. To investigate this, we used an <i>in vitro</i> biofilm model containing bacteria and fungi, reflective of the wound environment, to test the impact of antimicrobials. Here we showed that while monotreatment approaches influenced biofilm composition, this had no discernible effect on overall quantity. Only by combining bacterium- and fungus-specific antibiotics were we able to decrease the bi ...[more]
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