Ontology highlight
ABSTRACT:
SUBMITTER: Akera T
PROVIDER: S-EPMC5906099 | biostudies-literature | 2017 Nov
REPOSITORIES: biostudies-literature
Akera Takashi T Chmátal Lukáš L Trimm Emily E Yang Karren K Aonbangkhen Chanat C Chenoweth David M DM Janke Carsten C Schultz Richard M RM Lampson Michael A MA
Science (New York, N.Y.) 20171101 6363
Genetic elements compete for transmission through meiosis, when haploid gametes are created from a diploid parent. Selfish elements can enhance their transmission through a process known as meiotic drive. In female meiosis, selfish elements drive by preferentially attaching to the egg side of the spindle. This implies some asymmetry between the two sides of the spindle, but the molecular mechanisms underlying spindle asymmetry are unknown. Here we found that CDC42 signaling from the cell cortex ...[more]