Ontology highlight
ABSTRACT: Conclusion
T2D is independently associated with increased risk for HCC in two prospective cohorts of U.S. men and women. This risk is enhanced with prolonged diabetes duration and with comorbid metabolic conditions, suggesting the importance of insulin resistance in the pathogenesis of HCC. (Hepatology 2018;67:1797-1806).
SUBMITTER: Simon TG
PROVIDER: S-EPMC5906170 | biostudies-literature | 2018 May
REPOSITORIES: biostudies-literature
Simon Tracey G TG King Lindsay Y LY Chong Dawn Q DQ Nguyen Long H LH Ma Yanan Y VoPham Trang T Giovannucci Edward L EL Fuchs Charles S CS Meyerhardt Jeffrey A JA Corey Kathleen E KE Khalili Hamed H Chung Raymond T RT Zhang Xuehong X Chan Andrew T AT
Hepatology (Baltimore, Md.) 20180326 5
Type 2 diabetes (T2D) is a risk factor for hepatocellular carcinoma (HCC). However, it is unknown whether T2D duration or additional metabolic comorbidities further contribute to HCC risk. From the Nurses' Health Study (NHS), 120,826 women were enrolled in 1980, and from the Health Professionals Follow-up Study (HPFS), 50,284 men were enrolled in 1986 and followed through 2012. Physician-diagnosed T2D was ascertained at baseline and updated biennially. Cox proportional hazards regression models ...[more]