Depression and risk of epithelial ovarian cancer: Results from two large prospective cohort studies.

ABSTRACT:

Objectives

While emerging evidence supports a possible link between depression and ovarian cancer progression, no prospective studies have explored the association with ovarian cancer risk.

Methods

We prospectively followed 77,451 women from the Nurses' Health Study (1992-2010) and 106,452 women from the Nurses' Health Study II (1993-2011). Depression was defined as having one or more of the following: a 5-item Mental Health Index (MHI-5) score≤52, antidepressant use, or physician-diagnosed depression. Multivariable-adjusted Cox proportional hazards models were used to estimate hazard ratios (HRs) and 95% confidence intervals (CIs) for the association between depression and incident ovarian cancer.

Results

We documented 698 incident cases of epithelial ovarian cancer

SUBMITTER: Huang T 

PROVIDER: S-EPMC4679423 | biostudies-literature | 2015 Dec

REPOSITORIES: biostudies-literature