Ontology highlight
ABSTRACT:
SUBMITTER: Leem E
PROVIDER: S-EPMC5906475 | biostudies-literature | 2018 May
REPOSITORIES: biostudies-literature
Cell death & disease 20180501 5
The role of astrocyte elevated gene-1 (AEG-1) in nigral dopaminergic (DA) neurons has not been studied. Here we report that the expression of AEG-1 was significantly lower in DA neurons in the postmortem substantia nigra of patients with Parkinson's disease (PD) compared to age-matched controls. Similarly, decreased AEG-1 levels were found in the 6-hydroxydopamine (6-OHDA) mouse model of PD. An adeno-associated virus-induced increase in the expression of AEG-1 attenuated the 6-OHDA-triggered apo ...[more]