Ontology highlight
ABSTRACT:
SUBMITTER: Calvo-Rodriguez M
PROVIDER: S-EPMC7195480 | biostudies-literature | 2020 May
REPOSITORIES: biostudies-literature
Calvo-Rodriguez Maria M Hou Steven S SS Snyder Austin C AC Kharitonova Elizabeth K EK Russ Alyssa N AN Das Sudeshna S Fan Zhanyun Z Muzikansky Alona A Garcia-Alloza Monica M Serrano-Pozo Alberto A Hudry Eloise E Bacskai Brian J BJ
Nature communications 20200501 1
Mitochondria contribute to shape intraneuronal Ca<sup>2+</sup> signals. Excessive Ca<sup>2+</sup> taken up by mitochondria could lead to cell death. Amyloid beta (Aβ) causes cytosolic Ca<sup>2+</sup> overload, but the effects of Aβ on mitochondrial Ca<sup>2+</sup> levels in Alzheimer's disease (AD) remain unclear. Using a ratiometric Ca<sup>2+</sup> indicator targeted to neuronal mitochondria and intravital multiphoton microscopy, we find increased mitochondrial Ca<sup>2+</sup> levels associated ...[more]