Ontology highlight
ABSTRACT:
SUBMITTER: Rogne M
PROVIDER: S-EPMC5908127 | biostudies-literature | 2018 May
REPOSITORIES: biostudies-literature
Rogne Marie M Svaerd Oksana O Madsen-Østerbye Julia J Hashim Adnan A Tjønnfjord Geir E GE Staerk Judith J
Journal of cellular and molecular medicine 20180307 5
Cytokinesis failure leads to the emergence of tetraploid cells and multiple centrosomes. Chronic lymphocytic leukaemia (CLL) is the most common haematological malignancy in adults and is characterized by clonal B cell expansion. Here, we show that a significant number of peripheral blood CLL cells are arrested in cytokinesis and that this event occurred after nuclear envelope reformation and before cytoplasmic abscission. mRNA expression data showed that several genes known to be crucial for cel ...[more]