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An atlas of Wnt activity during embryogenesis in Xenopus tropicalis.

ABSTRACT: Wnt proteins form a family of highly conserved secreted molecules that are critical mediators of cell-cell signaling during embryogenesis. Partial data on Wnt activity in different tissues and at different stages have been reported in frog embryos. Our objective here is to provide a coherent and detailed description of Wnt activity throughout embryo development. Using a transgenic Xenopus tropicalis line carrying a Wnt-responsive reporter sequence, we depict the spatial and temporal dynamics of canonical Wnt activity during embryogenesis. We provide a comprehensive series of in situ hybridization in whole-mount embryos and in cross-sections, from gastrula to tadpole stages, with special focus on neural tube, retina and neural crest cell development. This collection of patterns will thus constitute a valuable resource for developmental biologists to picture the dynamics of Wnt activity during development.

SUBMITTER: Borday C

PROVIDER: S-EPMC5908154 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature

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An atlas of Wnt activity during embryogenesis in Xenopus tropicalis.

Borday Caroline C Parain Karine K Thi Tran Hong H Vleminckx Kris K Perron Muriel M Monsoro-Burq Anne H AH

PloS one 20180419 4

Wnt proteins form a family of highly conserved secreted molecules that are critical mediators of cell-cell signaling during embryogenesis. Partial data on Wnt activity in different tissues and at different stages have been reported in frog embryos. Our objective here is to provide a coherent and detailed description of Wnt activity throughout embryo development. Using a transgenic Xenopus tropicalis line carrying a Wnt-responsive reporter sequence, we depict the spatial and temporal dynamics of ...[more]

PMID: 29672592

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