Ontology highlight
ABSTRACT:
SUBMITTER: Jeong MY
PROVIDER: S-EPMC5908215 | biostudies-literature | 2018 Feb
REPOSITORIES: biostudies-literature
Jeong Mark Y MY Lin Ying H YH Wennersten Sara A SA Demos-Davies Kimberly M KM Cavasin Maria A MA Mahaffey Jennifer H JH Monzani Valmen V Saripalli Chandrasekhar C Mascagni Paolo P Reece T Brett TB Ambardekar Amrut V AV Granzier Henk L HL Dinarello Charles A CA McKinsey Timothy A TA
Science translational medicine 20180201 427
There are no approved drugs for the treatment of heart failure with preserved ejection fraction (HFpEF), which is characterized by left ventricular (LV) diastolic dysfunction. We demonstrate that ITF2357 (givinostat), a clinical-stage inhibitor of histone deacetylase (HDAC) catalytic activity, is efficacious in two distinct murine models of diastolic dysfunction with preserved EF. ITF2357 blocked LV diastolic dysfunction due to hypertension in Dahl salt-sensitive (DSS) rats and suppressed aging- ...[more]