Fetal growth is associated with CpG methylation in the P2 promoter of the IGF1 gene.
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ABSTRACT:
SUBMITTER: Le Stunff C
PROVIDER: S-EPMC5909239 | biostudies-literature | 2018
REPOSITORIES: biostudies-literature
Publications
Fetal growth is associated with CpG methylation in the P2 promoter of the IGF1 gene.
Le Stunff Catherine C Castell Anne-Laure AL Todd Nicolas N Mille Clémence C Belot Marie-Pierre MP Frament Nathalie N Brailly-Tabard Sylvie S Benachi Alexandra A Fradin Delphine D Bougnères Pierre P
Clinical epigenetics 20180419
<h4>Background</h4>There are many reasons to think that epigenetics is a key determinant of fetal growth variability across the normal population. Since <i>IGF1</i> and <i>INS</i> genes are major determinants of intrauterine growth, we examined the methylation of selected CpGs located in the regulatory region of these two genes.<h4>Methods</h4>Cord blood was sampled in 159 newborns born to mothers prospectively followed during their pregnancy. A 142-item questionnaire was filled by mothers at in ...[more]
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