Ontology highlight
ABSTRACT:
SUBMITTER: Whittington HJ
PROVIDER: S-EPMC5909653 | biostudies-literature | 2018 May
REPOSITORIES: biostudies-literature
Whittington Hannah J HJ Ostrowski Philip J PJ McAndrew Debra J DJ Cao Fang F Shaw Andrew A Eykyn Thomas R TR Lake Hannah A HA Tyler Jack J Schneider Jurgen E JE Neubauer Stefan S Zervou Sevasti S Lygate Craig A CA
Cardiovascular research 20180501 6
<h4>Aims</h4>Mitochondrial creatine kinase (MtCK) couples ATP production via oxidative phosphorylation to phosphocreatine in the cytosol, which acts as a mobile energy store available for regeneration of ATP at times of high demand. We hypothesized that elevating MtCK would be beneficial in ischaemia-reperfusion (I/R) injury.<h4>Methods and results</h4>Mice were created over-expressing the sarcomeric MtCK gene with αMHC promoter at the Rosa26 locus (MtCK-OE) and compared with wild-type (WT) litt ...[more]