Transcriptomics

Dataset Information

0

High-fat diet enhances food-seeking behavior via sensitizing hunger-sensing neurons in Drosophila I


ABSTRACT: The function of the central nervous system to regulate food intake can be disrupted by sustained metabolic challenges such as high-fat diet (HFD), which may contribute to the development of various metabolic disorders. In the present study, we found that HFD specifically enhanced food-seeking behavior in fruit flies without altering flies’ baseline metabolism and food consumption. Mechanistically, HFD increased the excitability of a small group of octopaminergic (OA) neurons to a hunger hormone named adipokinetic hormone (AKH), via increasing the accumulation of AKH receptor (AKHR) in these neurons. Upon HFD, excess dietary lipids are transported by a lipoprotein LTP to enter these OA+AKHR+ neurons via the cognate receptor LpR1, which in turn activated AMPK-TOR signaling and suppressed autophagy-dependent degradation of AKHR. Taken together, we uncovered a mechanism that linked HFD, AMPK-TOR signaling, neuronal autophagy, and food-seeking behavior, providing insight in the reshaping of neural circuitry under metabolic challenges and the progression of metabolic diseases.

ORGANISM(S): Drosophila melanogaster

PROVIDER: GSE129601 | GEO | 2019/04/11

REPOSITORIES: GEO

Dataset's files

Source:
Action DRS
Other
Items per page:
1 - 1 of 1

Similar Datasets

2019-04-11 | GSE129602 | GEO
2023-01-18 | GSE210333 | GEO
2023-01-26 | PXD039625 | Pride
2022-05-14 | GSE202707 | GEO
2016-05-03 | GSE73436 | GEO
2017-03-08 | GSE89731 | GEO
2019-10-04 | PXD014819 | Pride
2019-03-31 | GSE128413 | GEO
2022-07-14 | GSE207881 | GEO
2023-01-25 | GSE216697 | GEO